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Inserito il - 07 aprile 2008 : 22:50:13  Mostra Profilo  Visita l'Homepage di n/a Invia a n/a un Messaggio Privato  Rispondi Quotando
Valia sei forte. grazie veramente per i link ma io sono proprio negata per l'estero e preferisco l'italia. se sai qualcosa fammelo sapere ciao.
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Posizione di PhD biomedicina (immunologia/staminali) a Nijmegen (Olanda) - scadenza 12/05/2008


PhD student
Nijmegen, 6500 HB, (Gelderland), 36 hours per week
University Medical Centre Nijmegen

Job description
The PhD student participates in the project that defines the functional state of MiHA-specific CD8+ memory T cells and DC in transplanted patients, and to determine whether vaccination with MiHA-loaded DC can revive inactive memory T cells.
Carries out the research project
Publishes the results in scientific journals
Accomplishes a PhD thesis

Requirements
University Graduate
MSc degree in (Medical) Biology, Biomedical life science or Medicine
Ample experience with cell culture, flow cytometry, cellular immunology and molecular biology techniques
An independent and well-structured working style
Strong motivation to succeed in scientific and translational research

Additional information about the job:
Title project: Dendritic cell-mediated reactivation of functionally impaired T cells to improve graft-versus-tumor responses after allogeneic stem cell transplantation.

Allogeneic stem cell transplantation is a potent immunotherapy for hematological malignancies. The effectiveness is attributed to the graft-versus-tumor (GVT) response, during which donor-derived CD8+ T cells become activated by recipient minor histocompatibility antigens (MiHA) presented on dendritic cells (DC). Consequently, these alloreactive donor T cells clonally expand, acquire effector functions and kill MiHA-positive malignant cells. After the response, most alloreactive T cells die through apoptosis, while a small population remains to form a pool of long-lived memory cells. However, tumor relapses still occur despite the presence of MiHA-specific memory T cells in the patient for many years. This suggests that these T cells become inactive over time contributing to tumor evasion. Recently, a crucial role for the co-inhibitory PD-1/PD-L pathway in inhibiting the function of virus-specific CD8+ T cells was demonstrated in chronic viral infections. Hypothetically, PD-1 engagement by PD-L-expressing DC and tumor cells may also impair alloreactive CD8+ T cell function. Although the definite role of co-inhibitory signals in inducing functional impairment of MiHA-specific CD8+ T cells needs to be resolved, an appealing strategy to activate these T cells would be DC-based vaccination. In particular, mature DC providing increased co-stimulatory signals may overrule co-inhibitory signals inducing efficient reactivation of inactive CD8+ memory T cells. The purpose of this project is to define the functional state of MiHA-specific CD8+ memory T cells and DC in transplanted patients, and to determine whether vaccination with MiHA-loaded DC can revive inactive memory T cells. This project is supported by the Dutch Cancer Society.

Organization
University Medical Centre Nijmegen Central Hematology Laboratory/NCMLS

The "Immunotherapy" research group from the Central Hematology Laboratory focuses on immune mechanisms and target molecules involved in the graft-versus-tumor (GVT) response after allogeneic stem cell transplantation. Major topics include: investigation of the molecular identity and biological role of minor histocompatibility antigens (e.g. HB-1 and LRH-1), exploiting dendritic cells for the induction of specific GVT immunity, and development of dendritic cell-based vaccines to treat cancer patients after stem cell transplantation. The NCMLS is a research school of the Radboud University Nijmegen Medical Centre and integrates diverse scientific expertise in molecular and medical science for the advancement of innovation in translational research.

Conditions of employment
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 36

Additional conditions of employment:
Salary level 10A: maximal € 2572 gross per month

Additional Information
Additional information about the vacancy can be obtained from:

Mr. dr. H. Dolstra, scientific researcher
Telephone number: +31 24 361 97 53

Or additional information can be obtained through one of the following links.

* About the organization


Application
You can apply for this job before 12-05-2008 by sending your application to:

UMC St Radboud
227 COS
P. Claessen, HRM counselor
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
E-mail address: solliciteren@coscb.umcn.nl

When applying for this job always mention the vacancy number AT 08611.

The short URL code for this job opening is: 00385-2001.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/



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PhD immunologia a Nijmegen (Olanda) - Scadenza 30/05/08


PhD student
Nijmegen, 6500 HB, (Gelderland), 36 hours per week
University Medical Centre Nijmegen

Job description
The PhD student carries out the research project Transfusion-induced autoimmune hemolytic anemia: a biochemical and immunological identification of causes and consequences.
Publishes the results in scientific journals
Accomplishes a PhD thesis
Presents data, both written and orally

Requirements
University Graduate
MSc in (Medical) Biology, Medicine, or Chemistry
Experience in Biochemistry, cell culture, immunological techniques
An independent and well-structured working style
Well developed social skills

Additional information about the job:
Project title: Transfusion-induced autoimmune hemolytic anemia: a biochemical and immunological identification of causes and consequences.

Objective:
We propose the novel concept that accelerated erythrocyte aging during blood banking, associated with expression of neo-antigens and fast removal upon transfusion, induces generation of anti-erythrocyte antibodies and subsequent autoimmune hemolytic anemia (AIHA).
Therefore, we aim to:
1.Identify antigens on erythrocytes aging in vitro that induce auto-reactive antibodies upon transfusion.
2.Define signaling pathways that are responsible for the expression of these antigens during erythrocyte storage.
3.Design interventions that prevent antigen expression.
4.Define immunological pathways involved in anti-erythrocyte autoantibody formation.

Background
Physiological, age-dependent removal of erythrocytes is an efficient and well-regulated process, associated with a selective increase of autoimmune epitope expression. Also, erythrocytes contain a complex, functional set of regulatory systems that trigger their removal after injury. Modulation of regulatory pathways becomes progressively lost during storage, resulting in accelerated aging and fast removal of up to 30% of the transfused erythrocytes. Thus, accelerated aging may be associated with increased vesiculation and expression of pathogenic (autoimmune) epitopes on erythrocytes and their vesicles.
AIHA is a life-threatening disease, characterized by the development of auto-antibodies against erythrocytes, and by episodes with massive, antibody-caused hemolysis. AIHA occurs in 10% of the patients following erythrocyte transfusion. The mechanism behind this autoimmune response is not known, but it is clearly associated with a disturbed communication between erythrocyte and immune system. Studies in mouse AIHA models have implicated a loss of control by regulatory T cells (Treg) in this process.

Preliminary results
Our research group helped shaping the generally accepted concept that physiological erythrocyte aging leads to binding of autologous IgG followed by recognition and removal through phagocytosis. We have developed a procedure to isolate erythrocyte populations of well-defined ages. We have found indications that the accelerated appearance of aging antigens in banked erythrocyte concentrates leads to fast removal of up to 30% of the erythrocytes after transfusion.
IgG formation in AIHA is T cell-driven. The cellular basis of autoantibody formation is reflected by a change in the composition and functional capacities of leucocyte subsets. We developed a protocol for polyclonal ex-vivo expansion of small numbers of regulatory T cells (Treg) without loss of function. Preliminary data revealed a decreased Treg function in 4 out of 4 AIHA patients.

Proposed methods
1. Removal-prone erythrocytes will be isolated from transfusion units using a combination of volume and density centrifugation. Membrane proteins will be isolated by differential extraction, and analyzed for reactivity to patiënt sera and anti-erythrocyte antibodies. Subsequent mapping of the responsible epitopes will provide the first clues on identity, structure and mechanism of origin of the active antigens. The relevance of the various antibodies will be established by their binding to removal-prone erythrocytes using a very sensitive gel method.
2. Erythrocytes with an accelerated aging phenotype will be used to investigate the signaling pathways involved in the generation of the antibody-inducing antigens. Erythrocytes from transfusion units of various storage periods will be examined by immunoblotting and proteomics regarding the pathways that control exposure of phosphatidylserine, breakdown of membrane proteins, vesiculation, and calcium-regulated phosphorylation.
3. To manipulate the pathways that regulate auto-antigen expression, we will apply near-physiological treatments that are implicated in erythrocyte death in vivo. We will also examine the effects of intervention in pathways known to regulate metabolism and/or interaction between membrane and cytoskeleton, such as protein phosphorylation. These manipulations will be evaluated with regard to the generation of auto-antigens identified under (1).
4. To asses the T cell status in transfused patients with auto-antibodies, we aim to include 40 AIHA patients and 200 transfusion-dependent patients, and analyze these for the occurrence of anti-erythrocyte auto-antibodies prior to and after transfusion. Immunohematological assays will be used to detect antibodies and to determine their specificity. In antibody-positive patients and in negative controls, we will analyze functional and phenotypic characteristics of leucocyte subsets by flowcytometry, cytokine analysis and proliferation/suppression assays, with a specific focus on Treg. To examine reactivity against erythrocyte antigens, we will perform co-culture assays with T cells from antibody-positive patients, and measure reactivity against previously isolated cell and/or protein fractions from stored erythrocytes, and epitopes in the form of synthetic peptides.

Expected results:
These experiments will provide: (1) the identity of the epitopes that are responsible for the accelerated removal of stored erythrocytes after transfusion; (2) the mechanism(s) responsible for their generation; (3) clues to the methods to prevent their generation during blood banking; (4) clues as to how the T cell status of transfusion patients is relevant for anti-erythrocyte antibody formation.
The proposed project is based on a combination of ongoing research and areas of expertise of the department of Biochemistry on erythrocyte aging and signal transduction (Bosman, Willems, Brock), and those of the Department of Blood Transfusion and Transplantation Immunology (ABTI) on immune tolerance (Joosten and Novotny). This research is embedded in the in the Nijmegen Center for Molecular Life Sciences (Theme 1b. Immune regulation; I. Joosten, clinical PI and R. Brock, PI), and in the RUNMC programs Oncology (ABTI and Biochemistry) and Genetic and Metabolic Disorders (Biochemistry).


Organization
University Medical Centre Nijmegen ABTI

The department is a fully accredited medical and transplant immunology laboratory next to a blood transfusion service. Immunological research focuses on (clinical) tolerance induction in transplantation and auto-immune disease and transfusion, and the characterization and validation of biomarkers. T cell tolerance is one of the major topics, next to erythrocyte aging and the immune response. Research is embedded in the Nijmegen Centre for Molecular Life Sciences (NCMLS). The NCMLS integrates diverse scientific expertise in molecular and medical science for the advancement of innovation in translational research.

Conditions of employment
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 36

Additional conditions of employment:
Salary level 10A: maximal € 2572 gross per month

Additional Information
Additional information about the vacancy can be obtained from:

Mrs. dr. V.M.J. Novotny, hematologist / transfusionspecialis
Telephone number: +31 24 361 53 35

Mrs. dr. I. Joosten, immunologist
Telephone number: +31 24 361 53 35

Or additional information can be obtained through one of the following links.

* About the organization


Application
You can apply for this job before 30-05-2008 by sending your application to:

UMC St Radboud
227 COS
A. van der Heijde, HRM counselor
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
E-mail address: solliciteren@coscb.umcn.nl

When applying for this job always mention the vacancy number AT 08438.

The short URL code for this job opening is: 00385-1976.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/
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PhD farmacologia molecolare - Nijmegen (Olanda) - scadenza 3/05/08

PhD student
Nijmegen, 6500 HB, (Gelderland), 36 hours per week
University Medical Centre Nijmegen


Job description
_________________
The PhD student will design and perform scientific research in the area of (molecular) pharmacology in health and disease, for the project "The efflux pump, breast cancer resistance protein 1 (BCRP), as a novel pharmacological target to regulate peripheral steroid metabolism and insulin resistance". An, as yet unkown, mechanistic link between the efflux pump, breast cancer resistance protein (BCRP) and estrogen action is the central focus of this project. The PhD student:
Generates and analyses the data in order to contribute to scientific publications and present findings at scientific meetings
Works in a team with other students and scientists to discuss, plan and perform research in a stimulating environment
Works in an international research group
Completes the project with a scientific dissertation

Requirements
________________
University Graduate
MSc degree in (molecular) life sciences and experience with cell biological, biochemical and animal experimental studies
An independent and well-structured working style
Well developed social skills

Additional information about the job:
______________________________________
The project will be performed in close collaboration with the department of Chemical Endocrinology.

Organization
_______________
University Medical Centre Nijmegen Pharmacology and Toxicology

The molecular section of the department has a traditional strength in the field of drug transport and toxicity. The objective of the section is to examine the molecular and cellular mechanisms by which compounds foreign to the body are handled by transport proteins, with special reference to the role of these processes in drug efficacy and safety.

Conditions of employment
__________________________
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 36

Additional conditions of employment:
Salary level 10A: maximal € 2572 gross per month

Additional Information
_________________________
Additional information about the vacancy can be obtained from:

Mrs.dr. R. Masereeuw, associate professor
Telephone number: +31 24 361 37 30

Mr. Prof. dr. F.C.G.J. Sweep, head ACE,
Telephone number: +31 24 361 42 81

Or additional information can be obtained through one of the following links.

* About the organization


Application
_____________
You can apply for this job before 03-05-2008 by sending your application to:

UMC St Radboud
155 CBEG
M. Korsten, HRM counselor
P.O. Box 9101
6500 HB Nijmegen
The Netherlands
E-mail address: CBEG-solliciteren@cbeg.umcn.nl

When applying for this job always mention the vacancy number AT 08591.

The short URL code for this job opening is: 00385-1974.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/

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Città: Wageningen


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Dottorato in endocrinologia - Leiden (Olanda) - scadenza 12/05/08


PhD student, Endocrinology
Leiden, 2300 RC, (Zuid-Holland), 36 hours per week
Leids Universitair Medisch Centrum




Job description
The Department of Endocrinology is looking for a PhD student for its team examining the role of the brain in the regulation of triglyceride metabolism in plasma and adipose tissue. You will investigate how activation of the NPY neurons in the brain affects the triglyceride metabolism in plasma and adipose tissue and, as a result, resistance to insulin. The results should shed more light on the role of the brain in lipid metabolism and the development of type 2 diabetes mellitus and atherosclerosis as a consequence. Your work will involve biochemical research, including the use of humanised mouse models susceptible to both insulin resistance and atherosclerosis, and biochemical and molecular biology analysis.

Requirements
University Graduate
We are seeking a candidate with a university degree and a Radiation Hygiene 5B certificate as well as Art. 9 registration for working with laboratory animals. Experience and an interest in working with laboratory animals is essential, as is experience with biochemical research. You are pro-active and flexible and able to work independently and in a team. You should also be meticulous in your work.

Organization
Leids Universitair Medisch Centrum
At the Leiden University Medical Centre (LUMC), we are continually seeking to improve the quality of healthcare. The LUMC aims for excellence in patient care, research, teaching, training and continuing education. Department of Endocrinology works closely with TNO-Quality of Life and this project is financed by the Dutch Diabetes Research Foundation.

Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000

Maximum salary amount in Euro's a month 2572
Employment basis: Temporary for specified period
Duration of the contract: 4 years
Maximum hours per week: 36

Additional Information

Or additional information can be obtained through one of the following links.

* About the organization


Application
You can apply for this job by sending your application to:

LUMC
E-mail address: DIV2PenO@lumc.nl
What we offer
You will be employed on the basis of a 36-hour week. Appointment is for 4 years. Your salary will depend on your qualifications and experience, with a maximum of € 2,572 gross per month based on a full time position (scale for PhD students of the Collective Labour Agreement for University Hospitals).

Further information
If you have any questions, or if you want more information about this position, please contact Dr P.C.N. Rensen, Department of Endocrinology, telephone +31 (0)71 5261830, e-mail P.C.N.Rensen@lumc.nl, or Prof. J.A. Romijn, Department of Endocrinology, telephone +31 (0)71 5263082, e-mail J.A.Romijn@lumc.nl.

How to apply
If you are interested in the position listed above, and you meet the profile requirements, we welcome your application before 12 May 2008. You may apply by letter or by e-mail. Clearly state the job number of the position you are applying for. Please send your application, including your motivation and CV, to LUMC, Bureau Bedrijfsvoering Division 2 (K5-S), Personnel and Organisation Department, PO Box 9600, 2300 RC Leiden, The Netherlands. Please send your e-mail, including your motivation and CV to DIV2PenO@lumc.nl. Please ensure attachments to your e-mail, e.g. your CV, are in Microsoft Word.

When applying for this job always mention the vacancy number B.08.EK.09/AT18.

The short URL code for this job opening is: 00507-181.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/

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Postdoc fellow in Biochemistry (3 years) Utrecht (NL) - scadenza 13/5/08
38 hours per week
Utrecht University, faculty of Veterinary Medicine


Job description
The successful candidate will participate in a program on the regulation of oocyte competence by lipid droplets.

The dairy industry has suffered considerable financial losses as the fertility of the high yielding dairy cows has been declining over the last decades. There is a predominating opinion that the dramatic changes in (lipid) metabolism around parturition, the so called transition period, have a negative impact on reproduction parameters. This project is designed to determine the effect of a disturbed lipid handling by the oocyte during the transition period as a cause for its reduced reproductive capacity, providing more specific targets for drug testing. Recent evidence suggests that special organelles named lipid bodies or lipid droplets play an important role in lipid handling by cells. The relation between lipid droplet dynamics and oocyte competence will be investigated using state of the art techniques in mass spectroscopy (lipidomics), cellular imaging, and biochemical subcellular fractionation. The research will be executed in collaboration with our neighboring department of Farm Animal Health.

Requirements
University Graduate
We are looking for committed, enthusiastic individuals with a background in biomolecular science. The post-doctoral candidate should have a Ph.D. degree or equivalent. For the position comprehensive knowledge of intracellular membrane trafficking and dynamics is essential as well as affinity with biochemistry and/or mass spectroscopy. Candidates from the European Union are eligible for this position, or candidates with proven experience outside their native country. Relevant experience in biochemistry, (lipid) mass spectroscopy, and/or bioinformatics is an advantage.



Organization
Utrecht University, faculty of Veterinary Medicine
The Faculty of Veterinary Medicine www.vet.uu.nl is an internationally leading institute in veterinary scientific education, research and associated patient care. It ranks number one in Europe and among the top five institutes of veterinary science world-wide and is accredited by the American Medical Veterinary Association and the Canadian Medical Veterinary Association.

The Department of Biochemistry and Cell Biology invites applications for a


Postdoc fellow in Biochemistry

Conditions of employment
Estimated maximum salary per month: eur 3500 - 4000
Salaryscale 10.
Maximum salary amount in Euro's a month 3678
Employment basis: Temporary for specified period
Duration of the contract: 3 years
Maximum hours per week: 38

Additional conditions of employment:
We offer an experienced, collaborative and international group of colleagues and an excellent infrastructure that integrates molecular biology, biochemistry, life-cell imaging, and a state of the art lipidomics facility. We take part in the Institute of Biomembranes http://www.biomembranes.nl, the Academic Biomedical Centre http://www.abc.uu.nl and are engaged in many (inter)national collaborations.

We offer you a temporary fulltime appointment for 3 years.

Your gross salary will amount between € 2,804.- and €3,678.- per month (full-time appointment in scale 10, of the Collective Labor Agreement of the Dutch Universities), depending on previous qualifications and experience. There are outstanding secondary benefits, based on the CAO of Netherlands Universities and include e.g. a minimum of 31 days holiday per year, an arrangement for study facilities, generous contributions to healthcare, childcare, a pension scheme and flexible employment conditions.

Additional Information
Additional information about the vacancy can be obtained from:

Prof. Dr. Bernd Helms
Telephone number: 0)30 253 5375
E-mail address: j.b.helms@uu.nl

Or additional information can be obtained through one of the following links.


Application
You can apply for this job before 13-05-2008 by sending your application to:

Faculty of Veterinary Medicine
Personnel and Organisation
M.E.J. Willemse-van Soest
Yalelaan 1
3508 CL Utrecht
The Netherlands
E-mail address: vacatures1@vet.uu.nl
Sent your application accompanied by a curriculum vitae and the names and contact info of at least two persons who are able to provide professional reference, under the heading vacancy number 12841.

When applying for this job always mention the vacancy number 12841.

The short URL code for this job opening is: 00351-1510.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/

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Postdoc position in Molecular Microbiology - Groningen - scadenza 14/05/08
38 hours per week
University of Groningen


Job description
Postdoc position in molecular microbiology
for the project 'Physiological relevance of decarboxylation reactions in amino acid catabolism in LAB'.

Job description
Lactic acid bacteria growing on protein rich substrates in food fermentations are challenged with an excess of free amino acids that may be excreted or metabolized. Decarboxylation reactions play a role in the catabolism of amino acids at two different levels. One, direct decarboxylation of the amino acid, and, two, decarboxylation of a-keto-acids following transamination. The products of direct decarboxylation of aminoacids are biogenic amines that usually are unwanted in food fermentations. In contrast, decarboxylation of keto-acids may result in the formation of flavor compounds that may improve the quality of fermented food products.
It is believed that lactic acid bacteria benefit from decarboxylation pathways because of the production of metabolic energy and/or better survival in acidic environments. The global objective of the project is to identify the conditions under which the pathways are operative in the organisms to be able to control these in the fermentation process. The role of the postdoc is to determine the physiological relevance of the pathways by measuring parameters like growth rate and capacity, energetic parameters, acid resistance, pH homeostasis and viability. The experiments may be carried out using wild-type strains as well as metabolically engineered strains that, in part, will be constructed in the project.

Requirements
University Graduate
- the candidate has a PhD in biology/biochemistry with an interest in biotechnological applications of metabolic pathways in microorganisms
- good proficiency of the English language is required.

Organization
University of Groningen
Founded in 1614. One of the best universities in Europe and the world. A wide variety of disciplines. Internationally oriented. Rooted in the North of the Netherlands. Socially active. Our researchers and lecturers are inspired academics. Ambitious students. We respect the differences in talent, ambitions and performance of the 25.000 students and members of staff.

The university provides a career advisory service for partners of new staff who move to Groningen.

The university is an equal opportunities employer. Because women are still underrepresented in a number of fields, they are particularly encouraged to apply.

Faculty of Mathematics and Natural Sciences

Molecular Microbiology
The research group Molecular Microbiology is part of the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) in the Faculty of Mathematics and Natural Sciences of the University of Groningen. The group studies membrane-bound processes in bacteria, archaea and lower eukaryotes. Studies focus on the molecular mechanisms of transport, structural analysis of the membrane proteins involved, and the role of the transport processes in the physiology of the micro-organisms. The group has excellent research facilities and an international orientation.

Conditions of employment

Maximum salary amount in Euro's a month 3678
Employment basis: Temporary for specified period
Duration of the contract: One year with the perspective of prolongation for another year
Maximum hours per week: 38

Additional conditions of employment:
The University of Groningen offers a salary dependent on qualifications and work experience up to a maximum of € 3678 (scale 10) gross per month for a full-time position.The full time appointment is temporary of 1 year with the perspective of prolongation for another year following a successful mid-term review.

Additional Information
Additional information about the vacancy can be obtained from:

Dr. Juke S. Lolkema
E-mail address: j.s.lolkema@rug.nl

Or additional information can be obtained through one of the following links.

* About the organization
* Molecular Microbiology group

Letters in Dutch or English language, including the personal motivation for the position, a curriculum vitae along with names and addresses, including telephone/fax and e-mail addresses, of two referees must sent to: vmp@rug.nl

Application
You can apply for this job before 14-05-2008 by sending your application to:

Unviversity of Groningen
Personnel and Organization Office
P.O. Box 72
9700 AB Groningen
The Netherlands
E-mail address: vmp@rug.nl

When applying for this job always mention the vacancy number AT208123.

The short URL code for this job opening is: 00347-646.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/

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PhD-position Food Safety Management strategies based on acceptable risk and risk acceptance - Wageningen - (NL)- scadenza 30/05/08


38 hours per week
Agrotechnology & Food Sciences Group




Job description
PhD position Food Safety Management strategies
Microbiological food borne illnesses put a significant burden on societies around the world. Over the last 50 years international collaboration through Codex Alimentarius has made a strong effort to harmonise food safety standards and establish and share best practices in food safety management to improve consumer protection. Around the world, the framework of Risk Analysis has become more and more firmly established in governmental food safety control. This framework comes with a number of new concepts such as ALOP (the acceptable level of protection) and FSO (food safety objective). ALOP and FSO are established by governments only. To date there is a need to explore the scientific basis for establishing ALOPs and FSOs from risk analysis studies as well as to investigate alternatives for these targets or benchmarks for product safety. Alternatives might be based on currently well accepted management practices, for instance history of product safety, or on approaches used for chemical risks.

The PhD study will assess the current state of play regarding the inter-relationship between ALOP and FSO and identify weaknesses/gaps in science and technology to be addressed. It is planned to determine the magnitude of risks posed by different food-borne, microbial hazards and compare these to other risks that societies are exposed to. Views on the acceptance or acceptability of various risks and targets/benchmarks for the interpretation of product safety will be a key aspect of the work. The PhD project focuses on food microbiology, but may involve also aspects of consumer science and food toxicology. Contacts with governmental and inter-governmental organisations as well as with private organisations (e.g. industries, trade organisations) are likely.

Requirements
Doctorate
The candidate should have either an MSc-degree or equivalent in a discipline relevant to food safety, preferably food microbiology, with a genuine interest in food safety management. The candidate should be comfortable dealing with complex food safety management concepts and the analysis of large data sets. The project requires a dedicated and creative individual, with excellent organisational skills. The project will start as soon as possible.

Additional information about the job:
For further information about the project, please contact Prof. Dr.ir. M.H. Zwietering (+31 317 482233; Marcel.Zwietering@wur.nl), Prof. Dr. L.G.M. Gorris (+31 317 485358; Leon.Gorris@wur.nl) or Dr. Ir. M.W. Reij (+31 317 485358; Martine.Reij@wur.nl)
For information about the appointment please contact Mr. Rob van Meegen (+31 317 485466; Rob.vanMeegen@wur.nl).

Organization
Agrotechnology & Food Sciences Group
AFSG is the organisation for development and transfer of knowledge in the field of sustainable applications of agro-components for safe and healthy food and non-food products.

Conditions of employment
Estimated maximum salary per month: eur 2500 - 3000
Salaryscale 10.
Maximum salary amount in Euro's a month 2558
Employment basis: Temporary for specified period
Duration of the contract: 18 months + 30 months (after positive evaluation)
Maximum hours per week: 38

Additional conditions of employment:
We offer a PhD-position for 4 years with a starting salary of € 2000 gross a month for a fulltime appointment, increasing to a maximum of € 2.558 in the fourth year.
Initially the PhD appointment will be for a period of 18 months. Continuation of the appointment with another 30 months will be based on performance evaluation.
Hay-profiel: Promovendus

Additional Information
Additional information about the vacancy can be obtained from:

Prof.dr. M.H. Zwietering
Telephone number: +31 317 482233
E-mail address: marcel.zwietering@wur.nl

Prof.dr. L.G.M. Gorris
Telephone number: +31 317 485358
E-mail address: Leon.Gorris@wur.nl

Or additional information can be obtained through one of the following links.


Application
You can apply for this job before 30-05-2008 by sending your application to:

Wageningen UR - AFSG
bode 118
K. den Ridder
P.O. Box 17
6700 AA Wageningen
Netherlands
E-mail address: afsg-vacatures@wur.nl

When applying for this job always mention the vacancy number AFSG 08.060.

The short URL code for this job opening is: 00363-2629.
You can use this as a direct link to the job by adding the code to the URL www.academictransfer.org/
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Iside
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Iside_paradise

Città: Napoli


1375 Messaggi

Inserito il - 09 maggio 2008 : 17:20:32  Mostra Profilo  Visita l'Homepage di Iside  Invia a Iside un messaggio Yahoo! Invia a Iside un Messaggio Privato  Rispondi Quotando

-- SCADUTO --



Finalmente qualcosa anche in Italia!!!
Vi ricopio questa e-mail che mi hanno inviato:

FELLOWSHIP POSITION IN PEDIATRIC GASTROENTEROLOGY

We are looking for experienced cell/molecular biologists to join our team investigating intestinal signal mechanisms combining structure-function studies in humans.
We currently have openings for fellowship positions in the following projects:
• Bacterial modulation of intestinal ion transport, cell renewal and differentiation in enterocytes
• Role of functional nutrients in cell renewal and differentiation in enterocytes
• Relationship between oxidative stress and intestinal infections

The laboratory is located in the Department of Pediatrics of University of Naples “Federico II”, one of the most productive research unit in the pediatric gastroenterology in Italy.
Funding is available for a period of 2 years from October 2008. CV, lists of publications and a letter by a referee should be sent to Prof. A. Guarino by e-mail. Pre-application deadline is 31th May 2008.

e- mail: alfguari@unina.it
website: http://www.daspediatria.unina.it/

...we're just two lost souls swimming in a fishbawl...year after year...
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Ayla
Utente Junior

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Città: Wageningen


573 Messaggi

Inserito il - 26 maggio 2008 : 13:09:39  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando

-- SCADUTO --



15 PhD Positions in Molecular and Chemical Ecology, Jena, Germany - scadenza 30 Giugno 2008


The International Max Planck Research School (IMPRS) for the "Exploration of Ecological Interactions with Molecular and Chemical Techniques" in Jena, Germany, offers 15 PhD positions in molecular biology, ecology, entomology, microbiology, (bio)-chemistry, neuroethology or bioinformatics beginning in January 2009. The Research School is the first graduate school worldwide where modern chemical and molecular techniques are systematically linked to ecological research.

Students holding a Master’s degree (or equivalent) from any national and international university with a proven record of success in one of the relevant disciplines and being interested in examining traits of ecological interactions are eligible to conduct a doctoral project within the IMPRS. Courses of the IMPRS are held in English.

Application deadline is June 30, 2008.

For detailed information on the IMPRS, the application and admission procedures in Jena please visit our website http://imprs.ice.mpg.de/

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Ayla
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Città: Wageningen


573 Messaggi

Inserito il - 26 maggio 2008 : 13:11:32  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Postdoctoral position: INRA-Dijon Legume Research Unit, Dijon, France.



A postdoctoral position is available from October 1st 2008 for one year, renewable for a second year, at the INRA-Dijon Legume Research Unit (UMRLEG), to carry out a functional validation project in Pea. The genes of interest are potentially involved in pea seed yield and quality.

Legumes are bound to play a central role in sustainable agriculture and are a source of dietary protein for animal feed and human food. However, the development of these crops is limited by unstable seed yield and quality. Our main objective is to identify the genes controlling the quantitative variation of these traits. In this context, we searched TILLING mutants for 4 candidate genes. The project of the post-doctorate is (i) to characterise at the molecular and phenotypic levels the most interesting BC2S1 mutant lines obtained for different alleles of these genes to specify their role in the control of pea seed composition and size, and (ii) to search new alleles of these genes in the INRA pea germplasm collection.

Candidates should have a background and practical experience in basic molecular biology and genetics. The fellowship is restricted to non-French nationals who have not previously been employed in France.
Applications, which should include a curriculum vitae, list of publications, and contact details of two referees, should be sent by e-mail to: burstin@epoisses.inra.fr


Dr. Judith Burstin, INRA Unité Mixte de Recherches en Génétique,et Ecophysiologie des légumineuses à graines (UMRLEG), BP 86510, F-21065 DIJON FRANCE. Tel (00)33-380-693-159, Fax(00)33-380-693-263

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Ayla
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Città: Wageningen


573 Messaggi

Inserito il - 26 maggio 2008 : 13:14:09  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Postdoctoral position: University of Wisconsin-Milwaukee, USA.



A full-time postdoctoral position supported by the NSF is available in the laboratory of Dr. Dazhong Zhao at University of Wisconsin-Milwaukee.

The successful candidate will study the signaling mechanism underlying cell fate determination during Arabidopsis flower development. The successful candidate will employ molecular genetic, biochemical, cell biological and proteomic approaches to identify signaling molecules and their interactions in a receptor kinase-linked signal transduction pathway. Applicants should be highly motivated, independent, and collaborative. Experience in mutant identification and/or protein-protein interaction characterization is a plus, but not required. This position can be extended for up to three years.



All qualified candidates are encouraged to apply. Please email a cover letter, CV, and contact information for three references to Dazhong Dave Zhao: dzhao@uwm.edu

Review of applications will begin immediately, and will continue until the position is filled.
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AleXo
Moderatore

OrniAle

Prov.: Estero
Città: San Francisco, California


1550 Messaggi

Inserito il - 21 luglio 2008 : 18:06:59  Mostra Profilo  Visita l'Homepage di AleXo  Invia a AleXo un messaggio AOL Invia a AleXo un Messaggio Privato  Rispondi Quotando
PhD project in Investigative Toxicology


At Novartis: we want to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering and to enhance the quality of life. Our current product portfolio includes more than 45 key marketed products, many of which are leaders in their respective therapeutic areas. Currently, the development pipeline includes approximately 140 projects in various stages of development.

Investigative toxicology: is a unit of Preclinical Safety Assessment (part of Development) that investigates mechanisms of toxicity to prevent and solve pre-clinical and clinical drug safety issues, with a strong focus on new technologies and applying them to fundamental safety questions. Within investigative toxicology, the protein biology laboratory is offering a:
PhD student position (3 yrs)

Title: Evaluation of activity-based probes (ABPs) for functional characterization of
drug-target interactions

Project description: to explore the application of activity-based probes (ABPs) for assessing protein function. ABPs facilitate the imaging of enzyme activity in situ, ex vivo, and in vivo and provide a powerful tool to evaluate inhibitor efficacy. Furthermore, ABPs permit the identification of potential off-target interactors and the characterization of their functional relevance. The project requires a multi-disciplinary approach (chemical; molecular & cell biological; analytical) at the protein/enzyme, cell, and tissue levels to investigate mechanisms of toxicity. Collaborations with other groups within the Novartis Institutes for Biomedical Research, and regular input from an integrated team of scientists within the Novartis investigative toxicology department will be essential.

Requirements: A master degree in biochemistry, pharmaceutical science, biology, or toxicology, with a keen interest in multidisciplinary biochemical approaches to answer complex toxicology questions. The candidate will receive initial training but must rapidly become independent in setting his/her own program and experiments. Good presentation skills (writing of reports and peer reviewed articles as well as oral presentations of data to team members) and interpersonal (communication) skills are essential. Previous experience in enzyme assays, imaging, and inhibitor affinity binding studies are highly desired.
If you would like to further explore this possibility, please contact Dr. Rico Funhoff (enrico.funhoff[AT]novartis.com)

Selected reading
Evans, M.J. and Cravatt, B.F. 2006 Mechanism-based profiling of enzyme families. Chem. Rev. 106: 3279-3301
Gillet, L.L.C., K Namoto, A. Ruschti, S. Hoving, D. Boesch, B. Inverardi, D. Mueller, M. Goulot, P. Schindler, P. Schweigler, A. Bernardi, and S. Gil-Parrado. 2008 In cell selectivity profiling of serine protease inhibitors by actvity-based proteomics. Mol. Cellul. Proteomics, online available
Nomanbhoy, T. K., J. Rosenblum, A. Aban, and J. J. Burbaum. 2003. Inhibitor focusing: Direct selection of drug targets from proteomes using activity-based probes. Assay and Drug Development Technologies 1:137-146.

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0116_da_CIA

Città: Milano-Bologna


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Inserito il - 28 luglio 2008 : 14:42:12  Mostra Profilo  Visita l'Homepage di LaP Invia a LaP un Messaggio Privato  Rispondi Quotando
Per chi interessato al presente annuncio, rimando alla pagina di NatureJob: http://www.nature.com:80/naturejobs/science/jobs/62390

Project Leader: Method Developments in Liquid Chromatography-Mass Spectrometry
Summary
Employer:
Nestle Research Center (http://www.research.nestle.com)

Location:
Lausanne 1000 Switzerland

Posted:
July 14, 2008

Expires:
September 08, 2008

Tags:
lausanne, switzerland, project leader method developments in liquid chromatographymass spectrometry, development, bioinformatics, biological sciences, biotechnology, microbiology, nestle research center, project leader, project manager, Phd, mass spectrometry, liquid chromatography, lcms, method development, and method validation

Description


Nestlè Research Center (NRC) located near Lausanne, Switzerland is one of the leading research laboratories in food and nutritional sciences. With 700 members of staff from 50 nations, NRC has a strong position in the international scientific community supported further by 332 outside scientific contracts and 240 scientific publications in 2007 (learn more about the NRC on http://www.research.nestle.com).

NRC has an excellent reputation in food and nutrition research that has benefited consumers for over a century. By bringing together its knowledge in Nutrition and Health, Food Science, Food/Consumer Interaction, Food Quality and Safety, Nestlè opens the way to develop Good Food and Good Life: to offer tasty foods that procure health as well as pleasure for our consumers.

In this global and multicultural environment, Nestlè, a food, nutrition, health and wellness company aims to work with the best scientists in the world.

To support its research strategy, the Quality & Safety Department at the NRC is seeking a:

Project Leader: Method Developments in Liquid Chromatography-Mass Spectrometry

who will drive the internal and external development of mass spectrometry based methods, ensure the follow-up of the method implementation, and keep the group up-to-date in the field of mass spectrometry.

Main responsibilities:

• Lead developments of mass spectrometry-based methods (internally and externally) according to GLPs.
• Ensure appropriate contribution of collaborators within projects.
• Propose appropriate solutions with clients and external key contacts.
• Provide clients with advice and support upon request.
• Propose and set up a vision for future developments aligned with both current analytical advances and Quality & Safety Department strategy.

Required profile:

• PhD in mass spectrometry, with several publications.
• Strong experience in quantitative LC-MS.
• Experience in project management in a R&D environment.
• Experience in method validation.
• Oral and written English (French would be a plus)

Personal requirements:

• Ability to acquire new competences coupled with drive for consumer safety.
• Ability to communicate knowledge and results with coaching skills.
• Pragmatism, efficiency with hands on and decision making skills.
• Ability to write documents such as instructions, reports and publications.
• Willingness to travel.

If you interested in being involved in demanding and innovative research projects within one of the leading research laboratories in food and nutritional sciences worldwide, then apply with us now online on http://www.careers.nestle.com / Requisition ID number 2342 (i.e. complete application including CV, motivation letter and reference is mandatory).

Don't forget to mention naturejobs when replying to this advert
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Ayla
Utente Junior

guardiano

Città: Wageningen


573 Messaggi

Inserito il - 06 agosto 2008 : 11:34:00  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Ho sentito alla radio olandese l'annuncio per questo sito che offre posizioni in lab in industrie o aziende private
http://www.labrecruitment.com/default.asp

spero possa tornare utile... quasi quasi lo metto anche tra le segnalazioni (spero che i moderatori non se la prendano!)
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Ayla
Utente Junior

guardiano

Città: Wageningen


573 Messaggi

Inserito il - 06 agosto 2008 : 11:42:09  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Questo è un esempio di annuncio:
http://www.labrecruitment.nl/vacature.asp?id=443

Scusatemi, non mi è consentito dal sito copiare il testo, quindi lascio il link. E' per una posizione di biologo molecolare o informatico a Delft e gli va bene anche uno con sola triennale (BSc).
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tittideby
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65 Messaggi

Inserito il - 31 agosto 2008 : 20:25:56  Mostra Profilo  Visita l'Homepage di tittideby Invia a tittideby un Messaggio Privato  Rispondi Quotando
ciao ragazzi...mi aiutate???mi sono laureata ad aprile in biologia cellulare e molecolare ,laurea triennale,università di Bari.Ma con la lurea triennale che possiamo fare noi poevri biologi????e soparttutto.....per lavoare all'estero serve la specialistica????ad ottobre comincio la specialistica ma nel frattempo sto facendo la commessa in nun negozio di abbigliamento solo perchè mi pagano meglio che in un lab privato.....aiutoooooooooo!!!titti
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Ayla
Utente Junior

guardiano

Città: Wageningen


573 Messaggi

Inserito il - 06 ottobre 2008 : 09:43:59  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
12 PhD positions available in FINSysB



http://www.pasteur.fr/finsysb



Applications are being sought for twelve PhD positions in the FINSysB Network, starting October 1st, 2008. This Marie Curie Initial Training Network has been funded by the European Commission under Framework Program 7. The PhD’s will study with internationally renowned experts on a range of state-of-the-art projects involving genomics, molecular biology, bioinformatics and mathematical modeling (below). These projects will contribute to the overall FINSysB research program on the ‘Pathogenomics and systems biology of fungal infections – an integrative approach’. The successful applicants will be ambitious, conscientious and hard working team players. They will become integral members of the FINSysB Network where they will receive a thorough training in multidisciplinary research and complementary transferable skills, including career progression.



Applicants should send their CV with a covering letter to the relevant laboratory, specifying the PhD position of interest (e.g. FINSysB-PhD5). Applicants must meet the European Commission’s eligibility criteria. [For example: applicants must be in the first four years of their research careers; they can be nationals of any country other than the country where they will study for their PhD; and they must not have resided in the country of their PhD host for more than 12 months in the 3 years immediately prior to their recruitment.] Short-listed candidates will be interviewed by the host institution and will be reviewed centrally to ensure an appropriate gender balance across the Network. The successful applicants will hold contracts of employment with their host institution, and will be subject to the regulations of the European Commission.



PhD 1: Regulation of glucose and stress responses in C. albicans

Al Brown, Aberdeen University, UK: al.brown@abdn.ac.uk



PhD 2: Mathematical modeling of C. albicans stress responses that contribute to pathogenicity

Al Brown, Aberdeen University, UK: al.brown@abdn.ac.uk



PhD 3: Candidate diagnostics and therapeutic molecules for the detection and prevention of Candida infections

Andy Porter, Aberdeen University, UK: a.porter@abdn.ac.uk



PhD 4: Regulation of biofilm formation in C. albicans

Christophe d’Enfert, Institut Pasteur, Paris, France: denfert@pasteur.fr



PhD 5: Characterization of infection-associated genes required for interaction with host cells

Bernhard Hube, Hans Knoell Institute Jena, Germany: bernhard.hube@hki-jena.de



PhD 6: Efg1 regulatory circuits in C. albicans

Joachim Ernst, University of Duesseldorf, Germany: joachim.ernst@uni-duesseldorf.de



PhD 7: Contribution of cell wall proteins to C. albicans virulence

Claude Gaillardin, Institut National de la Recherche Agronomique, Thiverval-Grignon, France: Claude.Gaillardin@grignon.inra.fr



PhD 9: Development of anti-Candida vaccines

Frans Klis, University of Amsterdam, the Netherlands: klis@science.uva.nl



PhD 10: Immune signalling pathways induced by C. albicans - implications for therapy

Anna Vecchiarelli, University of Perugia, Italy: vecchiar@unipg.it



PhD 11: Patient Susceptibility to Candida infections

Mihai Netea, Radboud University Nijmegen Medical Center, the Netherlands: m.netea@aig.umcn.nl



PhD 12: Mathematical modelling of regulatory networks responsible for C. albicans virulence

Edda Klipp, Max Planck Institute for Molecular Genetics, Germany: klipp@molgen.mpg.de



More information on each position is available on the finsysb website at: http://www.pasteur.fr/finsysb
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Ayla
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Città: Wageningen


573 Messaggi

Inserito il - 06 ottobre 2008 : 09:46:54  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Post-Doctoral position in Plant Metabolism



IBMP, CNRS, France



The objective of the EU-funded SmartCell Collaborative project is to improve the production of new isoprenoids in plants, in particular the production of precusors of isoprenoid indole alkaloid anticancer drugs. The Strasbourg team has for mission to characterize relevant cytochrome P450 enzymes, in particular for the synthesis of iridoid derivatives. Candidate genes in Catharanthus roseus will be identified by european partners of the project. Other relevant genes in A. thaliana and grapevine will be identified on the basis of phylogeny or gene co-expression analysis recently developed in the laboratory. The candidate genes will be expressed in yeast, if relevant, co-expressed with co-regulated terpene synthases for functional screening and characterization. Selected candidates will further investigated for their function in planta. Gene function will be related to P450 evolutionary history. Functionally confirmed genes will also feed the pipeline of plant co-transformation and natural compounds production in plants for industrial application.



The EU-funded position is available for candidates with excellent academic record and confirmed experimental and communication skills. It is located in Strasbourg (France) for 24 months (possibly extended), starting January 2009. Salary is 2000-2200 euros per month.



Requirements:

Candidates must have a PhD with an excellent academic record. We are seeking individuals with a strong background in biochemistry, molecular biology, genetics, microscopy and, if possible, analytical chemistry. Experience in protein biochemistry and/or with fluorescent protein detection and confocal laser scanning microscopy is a plus.



Application:

Please send cover letter, CV, publication reprints and names and e-mail addresses of three references to Danièle Werck: daniele.werck@ibmp-ulp.u-strasbg.fr. The successful candidate will start between January 2009 and May 2009



IBMP is the largest CNRS research institute in plant science. It hosts 21 research groups and 188 staff members, including 104 permanents and 84 post-docs, PhDs and master students. It has a long-standing and respected expertise in the field of plant biology, including genomics, genetics, metabolism, biochemistry, enzymology, cell biology, and molecular physiology. It is organized in 4 scientific departments (Metabolic networks ; Virology ; Plant mitochondria ; Molecular mechanisms of phenotypic plasticity) and around 6 in house technological platforms (DNA sequencing and qPCR ; proteomics ; plant and plant cell culture ; cytology and cell imaging ; metabolomics ; bioinformatics). For more see : http://ibmp.u-strasbg.fr/



Further details and information: daniele.werck@ibmp-ulp.u-strasbg.fr

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Ayla
Utente Junior

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Città: Wageningen


573 Messaggi

Inserito il - 06 ottobre 2008 : 09:52:01  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Post-doc Plant Biotechnology - scadenza 24 ottobre 2008



Wageningen UR, Laboratory of Genetics, Wageningen, The Netherlands

Vacancy number: DPW 08-40



Wageningen University and Research Centre (Wageningen UR) is an international renowned knowledge institute in the fields of life sciences and sustainability. It makes an essential contribution to the quality of life through pioneering research and innovative education in the fields of health and nutrition, sustainable agricultural systems and a viable environment.



Wageningen Plant Sciences is a Wageningen UR consortium, bringing together the expertise of Wageningen University and the research institutes Plant Research International and PPO (Applied Plant Research). Dedicated to the field of plant-related research and education, Wageningen Plant Sciences has over 1800 staff members at 17 locations throughout the Netherlands.



The cooperation focuses on five expertise areas:

· Bioscience

· Breeding and Biodiversity

· Crop Ecology and Chain Innovations

· Biointeractions and Crop Protection

· Agrosystem innovations

In addition, applied research is carried out utilising specialist know-how and expertise in various sectors. Wageningen Plant Sciences also conducts a number of statutory research tasks.



Research group:

The Botanical Genetics section of the Laboratory of Genetics studies the genetic basis of natural variation in plants, mainly using the model plant species Arabidopsis thaliana or related Brassicaceae species. The research of the section is focused on the development of new genetic tools such as populations and lines, as well as ways to efficiently analyze them to advance the study of natural variation. Main areas of biological interest are plant growth and performance, adaptation to heavy metal exposure and plant nutrigenomics.



Project Information:

The ERGO project “Design of a decision matrix to assess GM crop impact on the detrital food web” aims to investigate how to determine risks of genetically modified food crop plants potentially damaging a healthy soil ecosystem by monitoring the effect of GM plants on detrivore soil organisms. In the project, transgenic Arabidopsis thaliana and Brassica plants will be constructed expressing Arabidopsis genes that are expected to enhance the content of specific anti-nutritional glucosinolates. These plants will be used by the collaborating partner in the project, the department of Animal Ecology of the Earth and Life Sciences faculty of the Vrije Universiteit Amsterdam, to study their effect on detrivore soil organisms. The project is expected to start soon.



Job Description:

Arabidopsis transcription factor genes known to control aliphatic glucosinolate biosynthesis will be cloned behind different promoters to create binary constructs for transformation of Arabidopsis, Brassica oleracea and B. rapa using Agrobacterium tumefaciens and A. rhizogenes mediated transformation methods. Transgenic plants need to be evaluated for gene expression and glucosinolate levels in pots and if possible in the field. Successfully modified plants will be multiplied for use in detrivore feeding studies by the VU partner.



Profile:

You have obtained a PhD in Plant Sciences or (Plant) Biotechnololgy, with a strong focus on molecular biology. You have experience in binary vector construction, plant transformations and analysis of transgenic plants. Experience with Arabidopsis and Brassica transformation is considered an advantage. You have published in high-rating international scientific journals. You value the benefits of collaboration, but are well able to perform independent research.



Remuneration:

This concerns a full-time position, 38 hours a week, for 3 years. Salary depends on experience (scale 10-11) with a maximum of €4284 per month.



Location: Wageningen



Information:

For more information you can contact Dr. Mark Aarts at the Laboratory of Genetics by phone (+31 317-485413) or e-mail: mark.aarts@wur.nl



Application:

Send your letter including CV before October 24th 2008 to Mrs. Hedwig Casteels, Department Personnel & Organization, P.O. Box 16, 6700 AA Wageningen, The Netherlands. E-mail: vacaturemeldingen.psg@wur.nl
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Ayla
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Città: Wageningen


573 Messaggi

Inserito il - 10 ottobre 2008 : 12:58:37  Mostra Profilo  Visita l'Homepage di Ayla Invia a Ayla un Messaggio Privato  Rispondi Quotando
Postdoctoral position in Fungal Signal Transduction and Pathogenesis
Department of Genetics, University of Cordoba, Spain



A two-year postdoctoral position will be open at the Department of Genetics, University of Cordoba, starting in January 2009. Our group is interested in the molecular mechanisms underlying fungal pathogenicity. As a model we are using Fusarium oxysporum, the causal agent of vascular wilt disease in plants and an emerging opportunistic pathogen of humans. Candidates will employ a variety of approaches to study transcription factors and virulence genes functioning downstream of conserved signalling cascades controlling invasive fungal growth on the host. Applicants should hold a PhD degree and have a strong background in molecular genetics and, ideally, signal transduction and/or plant-microbe interactions.

The Department of Genetics is a dynamic and multi-disciplinary center with state-of-the-art facilities, dedicated to research both at the fundamental and applied level. The city of Cordoba is located in the heart of Andalusia in Southern Spain, less than two hours train from Madrid and one hour from the Mediterranean coast.

Informal enquiries are welcome. Please submit applications including a cover letter, CV and names and contact information of at least 3 references to:

Prof. Antonio Di Pietro, Departamento de Genética, Universidad de Córdoba, e-mail: ge2dipia@uco.es

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chick80
Moderatore

DNA

Città: Edinburgh


11486 Messaggi

Inserito il - 24 ottobre 2008 : 09:29:41  Mostra Profilo  Visita l'Homepage di chick80 Invia a chick80 un Messaggio Privato  Rispondi Quotando
Posizione da post-doc sul ruolo delle E3 ligasi a San Diego (California)

Vedi allegato

Allegato: Postdoctoral ad.pdf
94,76 KB

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chick80
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DNA

Città: Edinburgh


11486 Messaggi

Inserito il - 28 ottobre 2008 : 09:29:47  Mostra Profilo  Visita l'Homepage di chick80 Invia a chick80 un Messaggio Privato  Rispondi Quotando
IRIBHM - Université libre de Bruxelles

Interdisciplinary Research Institute in Human Molecular Biology

Postdoctoral Position –Embryonic Stem Cells-Development

Applications are invited for a Postdoctoral position in the Interdisciplinary Research Institute in Human Molecular Biology (IRIBHM) to work on the mechanisms controlling Thyroid cells differentiation from ES cells.
Applicants should have a Ph.D and proficiency in cell biology, molecular genetics and molecular biology. Experience with mice is an asset. Good oral and written English language skills are highly desirable. Medical doctors with experience in research are also encouraged to apply.

The post will be held under the supervision of Dr Sabine Costagliola (PhD, FNRS - Senior Research Associate; http://costalab.ulb.ac.be).

The post is available immediately for three years (subject to satisfactory review at 12 month).

Applicants should include a covering letter outlining the reason for the interest in the post, a CV with publications and the name of two academic referees.

Applications should be made by email to Sabine Costagliola at scostag@ulb.ac.be

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Flap
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Inserito il - 01 settembre 2009 : 16:22:06  Mostra Profilo  Visita l'Homepage di Flap Invia a Flap un Messaggio Privato  Rispondi Quotando
Ciao ricercatori in giro per il mondo...qualche borsa di PhD per il 2010? Mi laureo in biologia cellulare e molecolare fra un mese e il posto di PhD che speravo di avere nel mio lab andrà ad altra gente che ha più diritto di me..sono disposta a spostarmi all' estero..anzi mi piacerebbe molto. Ho esperienza in clonaggi, espressioni in lieviti e batteri, purificazione di proteine...e tanto entusiasmo!!! Se qualcuno sa di qualche lab all' estero che cerca phD...tenterò..grazie.
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chick80
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DNA

Città: Edinburgh


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Inserito il - 01 settembre 2009 : 16:26:00  Mostra Profilo  Visita l'Homepage di chick80 Invia a chick80 un Messaggio Privato  Rispondi Quotando
hai provato su www.findaphd.com?

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