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Iside
Utente Attivo
Città: Napoli
1375 Messaggi |
 Inserito il - 10 gennaio 2008 : 14:07:19
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"Accurate splicing of pre-mRNA is a critical step in the gene expression pathway in eukaryotes. The exon–intron boundaries, known as the 5' and 3' splice sites, are defined by conserved sequences that are critical for the reaction. Because the splice-site consensus motifs are degenerate, many matches to each consensus are present along pre-mRNAs, but the vast majority of these sequences, known as pseudo splice sites, are never selected for splicing (1). Cryptic splice sites also match the consensus motifs, and by definition they are splice sites that are not detectably used in wild-type pre-mRNA, but are only selected as a result of a mutation elsewhere in the gene, most often at the authentic splice site."
Spero che vada bene.
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...we're just two lost souls swimming in a fishbawl...year after year...
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sito criptico
