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Messaggio inserito da Giuliano652

non le producono. Esattamente cosa vorrebbe dire "emolisine non tossiche"? Per definizione un'emolisina distrugge i globuli rossi, come fa a non essere tossica?

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alpha-hemolysin
Secreted by Staphylococcus aureus, this toxin causes cell death by binding with the outer membrane, with subsequent oligomerization of the toxin monomer and water-filled channels. These are responsible for osmotic phenomena, cell depolarization and loss of vital molecules (v.gr. ATP) leading to its demise.[6]
beta-hemolysin
Upon investigating sheep erythrocytes, its toxic mechanism was discovered to be the hydrolysis of a specific membrane lipid, sphingomyelin, which accounts for 50% of the cell’s membrane. This degradation was followed by a noticeable rise of phosphoryl choline due to the release of organic phosphorus from sphingomyelin and ultimately caused cell lysis.[7]
gamma-Hemolysin
Unlike beta hemolysin, it has a higher affinity for phosphocholines with short saturated acyl chains, especially if they have a conical form whereas cylindrical lipids (e.g. sphingomyelin) hinder its activity. The lytic process, most commonly seen in leucocytes, is caused by pore formation induced by an oligomerized octamer that organizes in a ring structure. Once the prepore is formed, a more stable one ensues, named #946;-barrel. In this final part, the octamer binds with phosphatidylcholine.[8 ]

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